inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, uv radiation, stress and etc. persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from t cells. these molecules (e.g. il-6, tnf-α, il-1β and il-17) are mostly pleiotropic cytokines involved i...

introduction: helicobacter pylori (h. pylori) is a gastric pathogen of primates and causes active chronic gastritis as well as peptic ulcers. a wide range of studies is in effect to prevent or cure helicobacter infection and thus its associated disorders. in order to test various drug regimens as well as potential vaccines against h. pylori infection, a suitable animal model is required which s...

Inflammatory condition is the consequence of defensive mechanism of immune system against viral and bacterial infection, tissue injury, UV radiation, stress and etc. Persistently acute inflammation leads to chronic phase which is characterized by production of pro-inflammatory mediators from T cells. These molecules (e.g. IL-6, TNF-&alpha, IL-1&beta and IL-17) are mostly pleiotropic cytokines i...

objective(s): gastroesophageal reflux disease (gerd) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. in the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspiratio...

We studied the relationship between gastroduodenal inflammation and the presence of Campylobaeter pylori from biopsy specimens of the gastric mucosa in 91 patients with gastritis with or without ulcers and 9 controls, healthy or suffering from other diseases. 68 of the patients were positive for the presence of C. pylori in their gastric mucosa. C. pylori was confirmed bacteriohistological...

we studied the relationship between gastroduodenal inflammation and the presence of campylobaeter pylori from biopsy specimens of the gastric mucosa in 91 patients with gastritis with or without ulcers and 9 controls, healthy or suffering from other diseases. 68 of the patients were positive for the presence of c. pylori in their gastric mucosa. c. pylori was confirmed bacteriohistologically in...

Gastric cardia cancer (GCC) is a highly aggressive disease associated with chronic inflammation. To investigate the relationship between DNA damage response (DDR) and chronic inflammation, we collected 100 non-tumor gastric cardia specimens of Chaoshan littoral, a high-risk region for esophageal and gastric cardia cancer. A significantly higher proportion of severe chronic inflammation was foun...

Chronic inflammation contributes to a wide variety of human disorders. In the stomach, longstanding gastritis often results in structural alterations in the gastric mucosa, including metaplastic changes and gastric cancers. Therefore, it is important to elucidate factors that are involved in gastric inflammation. Nardilysin (N-arginine dibasic convertase; Nrdc) is a metalloendopeptidase of the ...

Colonization with Helicobacter pylori eventuates in varied clinical outcomes, which relate to both bacterial and host factors. Here we examine the relationships between cagA status, serum and gastric juice antibody responses, and gastric inflammation in dyspeptic patients. Serum, gastric juice, and gastric biopsy specimens were obtained from 89 patients undergoing endoscopy. H. pylori colonizat...

Chronic inflammation increases the risk of developing several malignancies, including gastric cancer. A better understanding of how inflammation promotes gastric oncogenesis is therefore urgently needed. We have recently developed and characterized a mouse model that will be useful to elucidate the molecular and cellular circuitries bridging inflammation and gastric cancer.